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Overview: TMG 500 (trimethylglycine) TMG tablets (Jarrow) Each bottle, 120 tablets, each tablet 500 mg of trimethylglycine (anhydrousbetaine). TMG is extracted from sugar beets. It consists of the amino acid glycine with three methyl (CH3) groups attached. For hypermethylation it makes the most sense when used in conjunction with B6, folic acid and B12. Along with vitamin B6 and folic acid, TMG (also known as betaine) reduces homocysteine levels, increases of which are associated with atherosclerosis. Most of TMG's activity appears to occur in the liver. TMG may help to increase S-adenosylmethionine (SAMe) levels in a safer way than methionine. Also, it may increase plasma and cerebrospinal levels of SAMe which have been observed to be reduced in some people with HIV (see SAMe and betaine entries). Due to one test tube study that showed enhanced bacterial growth, you might want to drop this supplement during an infection. It is not clear if this happens in humans, but prudence dictates caution. Suggested use is 1-2 tablets daily with meal or as directed. Reduce dose if headaches occur. Note that a 2002 Finnish studys howed significant decreases in homocysteine levels--but they used a fairly high dose of 6 grams per day.
Usage: Take 1 to 2 tablets daily with a meal, or as directed by your qualified health consultant. Keep tightly closed. Store in a cool, dry place.
TMG 500 contains Trimethylglycine (TMG) extracted from sugar beets. TMG is also known as anhydrous betaine. TMG is a highly effective donor of methyl groups and is a powerful reducer of homocysteine to biologically safe methionine.
Homocysteine is a toxic transient metabolite of methionine and is a significant heart risk factor. Homocysteine is reduced back to biologically safe methionine by methyl groups donated by TMG and enzymes that require Folic Acid, B12 and methyl groups or back to cysteine by B6.
Methylation is inhibited by inadequately functioning key enzymes, excessive protein and fat intake, poor diet, inadequate intake of methyl groups, coffee, alcohol or by smoking.
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These statements have not been evaluated by the food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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SUPPLEMENT FACTS
Serving Size 1 Tablet
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Amount |
% DV |
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Trimethylglycine (Anhydrous Betaine)
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500 mg |
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* Daily Value not established.
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Other Ingredients: Dicalcium phosphate, modified cellulose gum, silicon dioxide and magnesium stearate.
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