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Overview:Milk Thistle/ Silybin Advanced (Enzymatic Therapy) Each bottle 60 capsules. Each capsule contains 120 mg of Milk Thistle standardized for 120 mg of Silybin. UltraCleanse Silybin (Silybum marianum) Fruit One part Silybin (from milk thistle extract) bound to two parts phosphatidylcholine (soy) using a proprietary process for improved absorption (also known as a phytosome or liposome). Basically, the silymarin are fat-soluble so they absorb much better with a bit of fat. Some drugs, like liposomal doxorubicin, use a similar technology. Suggested use is 1 or 2 capsules per day.
Other ingredients include cellulose, vegetable capsule (modified cellulose), magnesium stearate, and silicon dioxide. Contains no sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, preservatives, or ingredients of animal origin. This product contains natural ingredients; color variations are normal.
Milk Thistle: Silymarin (Silybum Marianum) A potent liver-strengthening herb, it stimulates the liver to regenerate itself by producing new liver cells as well as having strong antioxidant action to help prevent lipid-peroxidation of cell membranes. Given to seven patients receiving tuberculosis drugs (INH and ethambutol), a standardized silymarin extract normalized elevated liver enzymes after three months treatment. Many people with hepatitis C use milk thistle. It is extremely safe. Some studies suggest it may help to reverse the scarring known as fibrosis. Chilean researchers have discovered that silymarin increases glutathione in the liver, stomach and intestines by over 50% although it was not shown to increase GSH levels in other organs. Milk thistle may interact with cytochrome P450--specifically the 3A4 enzyme. This is important since it is used by many AIDS drugs. A study by Piscitelli, et al., happily, found no effect on the plasma level of indinavir (Crixivan). Now we needa study evaluating the potential benefit against the liver toxicities of drugs like nevirapine and ritonavir (Norvir). Anecdotal reports suggest that it may delay CD4 increases with ARV. See also entries on Dandelion Root as well as Hepato-C, Hepato-Detox and Ecliptex (Chinese Herbal Formulae).
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