Cardio-Edge (Douglas Labs) Each bottle, 120 vegetarian capsules. Each capsule contains:

Plant sterols (phytosterols) from soy - 200 mg
Sytrinol - 75 mg
Standardized pomegranate extract (fruit; standardized to 40% ellagic acid) - 25 mg

Sytrinol is a proprietary extract of polymethoxylated flavones and tocotrienols from citrus and palm fruits. Suggested use is two capsules taken twice per day.

This is somewhat similar to the Moducare product, although that product has less sterols and is derived from pine. No clinical trials have compared the efficacy of either in a comparative fashion.

Cardio-Edge is designed to help maintain cardiovascular health and support healthy cholesterol levels. Sytrinol is intended to have the following effects, some of which you can monitor with routine bloodwork to assess its effect for you. These include:
1) Decrease apoprotein B, needed for LDL synthesis
2) Decrease action of an enzyme in the liver that makes triglycerides
3) Inhibit HMG-CoA reductase in the liver

Patented combination of citrus PMFs and alpha, delta and gamma tocotrienols derived from palm fruit (U.S. patents #6,251,400, and #6,239,114). Palm tocotrienols have been shown to inhibit HMG CoA reductase, the enzyme responsible for regulating cholesterol synthesis in the liver. Clinical studies in both animals and humans support Sytrinol's role in reducing total and LDL-cholesterol as well as triglycerides.

Plant Sterols
Blood cholesterol is derived from the diet and synthesized in the liver. Sterols work by reducing the absorption of both forms of cholesterol - Sterols compete with cholesterol for absorption. Sterols and sterol esters can now be found in many foods including orange juice, rice drink, and margarine.

Pomegranate
Recent science has been focusing on the cardioprotective aspects of pomegranate. These brightly colored fruits contains numerous cornpounds known for their antioxidant capabilities, induding anthocyanidins, catechins, tannis, and gallic and ellagic acids. Research has shown that supplementation with pomegranate juice can decrease macrophage lipid accumulation, and cellular cholesterol accumulation in mice. Recently, research in humans has confirmed a beneficial effect of consuming pomegranate juice on parameters such as LDL oxidation, blood pressure, and blood vessel health.

In human clinical studies involving hypercholesterolemic subjects, no side effects were observed and four weeks of supplementing with a daily dose of 300 mg of Sytrinol.