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Glutamine, powder (NYBC-Montiff) Each bottle, 1,000 grams of powder (a kilogram or 2.2 pounds). Each 1/4 kitchen teaspoon has 700 mg. Suggested use is a quarter teaspoon (700 mg) in juice 1 to 3 times a day, between meals. However, some PWHIV are using a loading dose of up to 9 grams per day for 4 to 6 weeks, and then tapering it down by 50% in the hopes of reducing infections, increasing absorption and lessening severe inflammation along the GI tract. Higher doses (up to 30+ grams per day) are being used for weight gain and/or very severe intestinal inflammation. Many mix their amino acid powders together or put them in their protein powder.
(See also the entry for glutamine caps.)
Store unopened container at room temperature. Do not store at extreme temperatures. Once opened, reseal container and store in a cool, dry place (not refrigerator).
Additional info....
Glutamine is used to treat leaky gut which results when intestinal tissues are damaged. Glutamine is taken up in cells of the intestine (enterocytes) and then oxidized, strengthening the overall structure. It stimulates skeletal muscle protein synthesis as well and researchers at Case Western feel it may help, as a possible treatment for cirrhosis, to lower the levels of cytokines like IL-1, IL-6 and TNF which are also elevated in chronic HIV infection. This product is principally used to counteract maldigestion in PWHIV.
Clinical research has shown that people with protease-inhibitor diarrhea find relief using 30 to 40 grams per day. Start with about 15 grams per day and increase the dose until the diarrhea is controlled. Each kitchen teaspoon is about 5 grams. A daily maintenance dose is one teaspoon a day.
Unless you have diarrhea or other signs of malabsorption (and short of the loading dose approach discussed below), a daily dose of about 5 grams a day is probably enough. One concern NYBC has is that glutamine may readily transform into glutamate--and this could cause problems. Excessive levels of glutamate may interfere with the function of nerves and even block the cell
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