Horsechestnut Pro (MMS) Each bottle, 90 capsules. Each capsule, 250 mg of horsechestnut seed extract, 20% aescin, along with 100 mg of Calendula flower. Derived from the beautiful Aesculus hippocastanum. Some studies were conducted that showed a significant improvement in reducing lower limb edema. It appears to help with circulation and maintain the tone of veins.

Brinker's book, Herb Contraindications, lists this herb as containing an hydroxycoumarin component, and thus states that taking it with coumadin or aspirin may enhance bleeding effect (though they note this is a speculative effect). The bark is also sometimes used externally on ulcers. Grieve also notes that it has "tonic, narcotic and febrifuge properties." The Handbook of Clinically Tested Herbal Remedies notes that it was studied and found helpful in 3 well-conducted, placebo-controlled studies of people with chronic venous insufficiency (using 100 to 150 mg of aescin per day)...they do not suggest any adverse reactions (sometimes gastric side effects) or drug interactions, contrary to Brinker's. They note that it helps to reduce edema and swelling.

Bartram's Encyclopedia of Herbal Medicine notes that Horsechestnut tones and protects blood vessels, noting that it is sometimes used with Cowslip for varicose veins. Used traditionally for bleeding piles, uterine bleeding, etc....so it may possibly reduce risk of bleeding, rather than increase the risk.

Suggested use is 1 capsule, twice daily with water at mealtimes.

Cautions: Do not use if you have kidney or liver disease. Do not use if pregnant or nursing. While it is only speculative, it is wise to closely watch bloodwork if you are taking blood thinners like coumadin (warfarin) or aspirin.