Melatonin, sublingual (Douglas Labs) Each bottle, 60 tablets. Each tablet contains 3 mg of melatonin in an orange, sublingual form. Take one hour before bedtime. Take at the same time each night. You may slowly increase the dose up to about 3-5 mg per night.

Melatonin counteracts insomnia, depression, jet lag and may play a critical role in stabilizing or improving immunosuppression, Alzheimer’s and some cancers. It is a hormone produced by the pineal gland in the brain. DO NOT GIVE to infants, children and adolescents. Do not use if pregnant. Only use under a physician's care if you have an autoimmune disease, diabetes, a depressive disorder, a thyroid condition, epilepsy, leukemia or a lymphoproliferative disorder or if you are using MAO inhibitor drugs or corticosteroids (hydrocortisone or prednisone). Long-term use at high doses is not a good idea.

Many PWHIV have reported dramatically improved sleep patterns and relief from depression with this extract of the pineal gland. In animal laboratory models, European researchers were unable to create a CD4 cell loss under stress conditions when the animals had been given melatonin. For as interesting as melatonin is, there are sadly no studies in people with HIV. Some tantalizing test tube data even suggest some activity against various HIV proteins--but, of course, it is a long way from there to what happens in humans! Studies in older mice suggest that melatonin can impact on zinc turnover (important for immune function) which can restore thymus weight and expression of T cells among aging mice. TAKE ONLY AT NIGHT, about 1 hour before bed time, the SAME time each night. If you are going out late, SKIP that night entirely.