Overview: Coenzyme Q10 (CoQ10) is present in nearly every cell in the body and is responsible for the transfer of energy inside the cell. Because of this transfer capacity, CoQ10 can be thought of as a potent antioxidant since it reduces the loss of unstable electrons (free radicals) in the process of cell metabolism. Also, coenzymeQ10 resides in the fatty portions of the mitochondrial membrane where it acts as a potent antioxidant reactivating vitamin E and sparing the destruction of beta carotene. Coenzyme Q10 (ubiquinone) plays an important role in proper function of the mitochondrial electron transport system (ETS). The ETS is responsible for the production of adenosine triphosphate (ATP), the molecular source of energy that is used by the cell, during cellular respiration. The ETS becomes overworked during times of excessive or hypermetabolic conditions, especially during times of wasting syndrome. That is because the body needs more ATP to run things. But for every molecule of ATP formed, free radicals are generated too.

Note that one study showed an increase in pain among people suffering from neuropathy when they used 200 mg per day of CoQ10. Whether that was directly related to the CoQ10 supplementation or not needs to be further evaluated.

If the necessary antioxidants are available (glutathione, catalase, superoxide dismutases), there is no problem. But, as we’ve seen, these diminish or are overwhelmed by the generation of free radicals. CoQ10 is part of the process of passing electrons along that help to form new ATP.CoQ10 is synthesized by the body in small amounts, but more may be needed, especially in times of stress. CoQ10 operates in the inner membrane of a cellular organ called the mitochondria. Mitochondria produce ATP, which is essential for life; they may be damaged by long term use of nukes. Whether CoQ10will offset this, we don't know but many clinical studies have been done which show a value for helping with cardiomyopathy (although improvements in heart rhythms may take several weeks of use).

Clinical studies have shown repeatedly that coenzyme Q10 has potent abilities to assist the heart muscle, and as an adjunct treatment for angina, congestive heart failure, arrhythmia, hypertension (high blood pressure), and drug toxicity. Research has shown that as cellular levels of coenzyme Q10decrease, HIV disease progresses. Other studies have documented its immune restorative qualities, including restoration of T cell function. Absorption of dietary fat soluble coenzyme Q10, due to the high inflammatory cytokine levels, is disrupted, so supplementation may help. Many PWHIV believe CoQ10 is an important nutrient to aid in detoxification if one uses nucleoside analogues (AZT ddI, ddC, d4T, etc.) or any toxic drug. Due to this impaired absorption, it’s best to take a form of CoQ10 that is mixed with lecithin or some other fat to improve its uptake. However, it may be that only very high doses will help (like 200-400 mg a day!) This won’t be cheap.CoQ10 is very helpful in conjunction with certain drugs. Studies have shown clear benefit when used with a heart toxic chemotherapy drug called adriamycin. In addition, some have suggested that it is very important to use CoQ10 when taking one of the statin drugs, used to manage high LDL cholesterol since the level of CoQ10 in the blood is depleted when using this class of drugs. How well it works or what benefit CoQ10 may have in the context of HIV disease has not yet been clinically evaluated. (How many times do we have to write that??? These studies need to be done!!!)

There is a wide variety of dosing of CoQ10 in the HIV community, however many take their CoQ10 with the fattiest meal of the day in order to increase absorption. Those concerned with drug toxicity (particularly AZT) take at least 60 mg per day, though this is probably too low a dose. Studies that have shown benefit used doses ranging from 125-200 mg per day. Some PWHIV who have high blood pressure, heart complications, or are on a number of different toxic drugs (especially statins for cholesterol) use higher doses of around 200-400 mg per day. Unfortunately, the higher the dose, the greater the cost for this already expensive supplement.

USAGE: Take 1 to 3 softgels per day with food, or as directed by your qualified health consultant.

Q-absorb™ is a completely natural proliposome lipid soluble delivery system clinically shown in humans to increase Co-Q10 levels up to 400% (3.2x) over baseline and 3-4 times better absorbed than chewable Co-Q10 tablets. Co-Q10 supports heart function as a component of the electron transport system, and as an antioxidant protects mitochondrial membranes and cholesterol from oxidation.

Jarrow Formulas® Co-Q10 is derived from fermentation and consists only of the natural trans configuration, the same as synthesized by humans. Jarrow FORMULAS® supports clinical research on Coenzyme Q10.
Keep out of the reach of children.

Other Ingredients: Lecithin, medium chain glycerides (MCGs). Softgel consists of gelatin, glycerin and water. Carob extract added as a light barrier.

Particle formation inside softgel is normal and dissolves after ingestion.